Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction
| Autor: | Isabelle M. Côté, Philip J. Scarpace, Sara M. Green, Nihal Tümer, Drake Morgan, Christy S. Carter |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Food intake Physiology Adipose tissue Peptides Cyclic Fat mass Eating 03 medical and health sciences 0302 clinical medicine Central melanocortin system Physiology (medical) Internal medicine Hypophagia medicine Animals Caloric Restriction Pharmacology Control level Chemistry Body Weight Caloric theory Melanotan II General Medicine Melanocortins Rats 030104 developmental biology Endocrinology medicine.anatomical_structure Adipose Tissue alpha-MSH 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 96:308-312 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2017-0440 |
| Popis: | Recent evidence indicate that melanotan II (MTII) reduces body mass independently of caloric reduction. Because MTII induces a transient hypophagia, caloric reduction is still considered a primary mechanism for MTII-mediated body mass loss. To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group. Food intake and body mass were recorded daily, and body composition was assessed biweekly. The present study demonstrates that central MTII-mediated body mass loss is only partially mediated by caloric restriction, and the long-term body mass loss is independent of the initial hypophagia. More importantly, central MTII administration induced a rapid but sustained fat mass loss, independently of caloric reduction. MTII-treated animals preserved their lean/fat mass ratio throughout the study, whereas PF animals underwent a transient reduction of lean/fat mass ratio that was only normalized when food intake returned to Control level. In summary, it can be concluded that activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction. |
| Databáze: | OpenAIRE |
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