The effects of hyper- and hypocarbia on intraparenchymal arterioles in rat brain slices
| Autor: | Christopher P. Harkin, John P. Kampine, William T. Schmeling, Neil E. Farber |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Central nervous system Vasodilation In Vitro Techniques Hippocampal formation Hippocampus Microcirculation Hypercapnia Rats Sprague-Dawley Hypocapnia Arteriole medicine.artery medicine Animals business.industry General Neuroscience Anatomy Carbon Dioxide Hydrogen-Ion Concentration medicine.disease Rats Perfusion Arterioles medicine.anatomical_structure Cerebrovascular Circulation Circulatory system business circulatory and respiratory physiology |
| Zdroj: | NeuroReport. 8:1841-1844 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199705260-00010 |
| Popis: | This investigation examined the direct effects of hyper- and hypocarbia on intracerebral resistance vessels within an intact neuronal synctium. Hippocampal rat brain slices were superfused with artificial cerebrospinal fluid (aCSF). Arterioles were located and diameter changes in response to alterations in aCSF carbon dioxide tension (pCO2) were monitored with videomicroscopy. Microvessels dose dependently dilated and constricted during hyper- and hypocarbia, respectively. A two-fold rise in pCO2 produced a 20% increase in diameter, while a 47% decrease in pCO2 vasoconstricted microvessels by 11%. This is the first model allowing the investigation of the direct actions of physiologic mediators on discrete intracerebral resistance vessels in situ. The results suggest that intracerebral microvessels significantly respond to changes in pCO2 and may be intimately involved in alterations in cerebral vascular resistance. |
| Databáze: | OpenAIRE |
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