Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology
| Autor: | Geoffray Monteuuis, Anne M. Mäkelä, J. Kalervo Hiltunen, Remya R. Nair, Kaija J. Autio, Antonina Shvetsova, Laura P. Pietikäinen, Alexander J. Kastaniotis, Zhijun Chen, Juha M. Kerätär |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cellular respiration Cell Respiration Mitochondrion 03 medical and health sciences chemistry.chemical_compound Acyl Carrier Protein Animals Humans Molecular Biology Fatty acid synthesis Cellular compartment biology Lipogenesis Fatty Acids Lipid metabolism Cell Biology Metabolism Lipid Metabolism Mitochondria Cell biology Acyl carrier protein 030104 developmental biology chemistry Biochemistry Mitochondrial biogenesis biology.protein Oxidation-Reduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:39-48 |
| ISSN: | 1388-1981 |
| Popis: | Mitochondria and fatty acids are tightly connected to a multiplicity of cellular processes that go far beyond mitochondrial fatty acid metabolism. In line with this view, there is hardly any common metabolic disorder that is not associated with disturbed mitochondrial lipid handling. Among other aspects of mitochondrial lipid metabolism, apparently all eukaryotes are capable of carrying out de novo fatty acid synthesis (FAS) in this cellular compartment in an acyl carrier protein (ACP)-dependent manner. The dual localization of FAS in eukaryotic cells raises the questions why eukaryotes have maintained the FAS in mitochondria in addition to the "classic" cytoplasmic FAS and what the products are that cannot be substituted by delivery of fatty acids of extramitochondrial origin. The current evidence indicates that mitochondrial FAS is essential for cellular respiration and mitochondrial biogenesis. Although both β-oxidation and FAS utilize thioester chemistry, CoA acts as acyl-group carrier in the breakdown pathway whereas ACP assumes this role in the synthetic direction. This arrangement metabolically separates these two pathways running towards opposite directions and prevents futile cycling. A role of this pathway in mitochondrial metabolic sensing has recently been proposed. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. |
| Databáze: | OpenAIRE |
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