Long-term pulmonary function and quality of life in adults after extracorporeal membrane oxygenation for respiratory failure
| Autor: | Sandra Diaz, Björn Frenckner, Maximilian V. Malfertheiner, Viktor von Bahr, Staffan Eksborg, K Gunilla Frisén, Bernhard Holzgraefe, Tanja Dobrosavljevic, Jan Hultman, Jonathan E Millar, Marika Lidegran, Håkan Kalzén |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Acute respiratory distress 030204 cardiovascular system & hematology Lung injury Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Extracorporeal Membrane Oxygenation medicine Extracorporeal membrane oxygenation Humans Radiology Nuclear Medicine and imaging Intensive care medicine Critical Care Outcomes Lung Retrospective Studies Advanced and Specialized Nursing Respiratory Distress Syndrome business.industry 030208 emergency & critical care medicine General Medicine After discharge Respiratory Function Tests Survival Rate Treatment Outcome Respiratory failure Quality of Life Female Cardiology and Cardiovascular Medicine business Safety Research |
| Zdroj: | Perfusion. 34(1_suppl) |
| ISSN: | 1477-111X |
| Popis: | Background: There is a significant long-term burden on survivors after acute respiratory distress syndrome, even 5 years after discharge. This is not well investigated in patients treated with extracorporeal membrane oxygenation. The objective of this study was to describe very-long-term (⩾3 years) disability in lung function and morphology, quality of life, mood disorders, walking capacity, and return to work status in extracorporeal membrane oxygenation survivors. Methods: Single-center retrospective cohort study on long-term survivors treated with extracorporeal membrane oxygenation for respiratory failure between 1995 and 2010 at a tertiary referral center in Sweden. Eligible patients were approached, and those who consented were interviewed and investigated during a day at the hospital. Results: A total of 38 patients were investigated with a median follow-up time of 9.0 years. Quality of life was reduced in several Short form 36 (SF-36) subscales and all domains of the St George’s Respiratory Questionnaire, similar to previous studies in conventionally managed acute respiratory distress syndrome survivors. A reduced diffusion capacity of carbon monoxide was seen in 47% of patients, and some degree of residual lung parenchymal pathology was seen in 82%. Parenchymal pathology correlated with reductions in quality of life and diffusion capacity. Symptoms of anxiety and depression were seen in 22% and 14%, respectively. Conclusion: A significant long-term burden remains even 3–17 years after extracorporeal membrane oxygenation treatment, similar to conventionally managed acute respiratory distress syndrome survivors. Future prospective studies are needed to elucidate risk factors for these sequelae. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|