The Relationship between the Adrenoceptor and Nonadrenoceptor-Mediated Effects of Imidazoline- and Imidazole-Containing Compounds
| Autor: | V. G. Wilson, Craig J. Daly, David J. Miller, John C. McGrath, John O’Dowd, A.G.B. Templeton, G. Singh, M. Nagadeh, C. M. Brown, A. MacKinnon, Anne O'Dowd, David A. Kendall, Darawan Pinthong |
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| Rok vydání: | 1995 |
| Předmět: |
Adrenergic receptor
Chemistry Receptors Drug General Neuroscience Clonidine-displacing substance Imidazoles Imidazoline receptor Muscle Smooth Dipeptides Pharmacology Clonidine General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Phentolamine History and Philosophy of Science Smooth muscle Receptors Adrenergic alpha-2 Tissue extracts medicine Animals Humans Imidazole Imidazoline Receptors medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 763:591-605 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | This article brings together work on imidazoline or imidazole-containing compounds concerned with the pharmacology of alpha-adrenoceptors, principally on smooth muscle, to illustrate how imidazolines have contributed to the subclassification of alpha-adrenoceptors and how, against this background, attempts have been made to use this knowledge to uncover "nonadrenoceptor"-mediated biological effects of previously uncharacterized compounds, notably imidazole-containing dipeptides and "clonidine displacing substance" (CDS). Recent data are included on (1) the pharmacology of UK-14304, (2) nonadrenoceptor actions of phentolamine, (3) the pharmacology of tissue extracts containing imidazole-containing dipeptides and CDS activity, and (4) ligand binding data at I1 and I2 sites. |
| Databáze: | OpenAIRE |
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