Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging

Autor: Chan Mi Kim, Jorge Sepulcre, Ibai Diez, Victor Montal, Alzheimer’s Disease Neuroimaging Initiative, William Orwig
Rok vydání: 2021
Předmět:
cognition
Male
Aging
Alzheimer&apos
0302 clinical medicine
Cognition
Cognitive decline
Research Articles
Aged
80 and over
Radiological and Ultrasound Technology
biology
05 social sciences
Neurodegeneration
Brain
Human brain
Alzheimer's disease
amyloid PET
Cognitive test
medicine.anatomical_structure
Neurology
Female
Anatomy
Connectivity analysis
Research Article
Amyloid beta
tau Proteins
050105 experimental psychology
s disease
03 medical and health sciences
mental disorders
medicine
Dementia
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Tau PET
Pathological
Aged
Amyloid beta-Peptides
business.industry
medicine.disease
Amyloid PET
Positron-Emission Tomography
biology.protein
Neurology (clinical)
connectivity analysis
Nerve Net
business
Neuroscience
030217 neurology & neurosurgery
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Human Brain Mapping
HUMAN BRAIN MAPPING
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
ISSN: 1065-9471
Popis: Amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to Aβ and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory‐based positron emission tomography (PET) analytical approaches, within and between tau and Aβ PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of Aβ and tau deposits, along with cognitive test scores in CN at both baseline and 2‐year follow‐up (FU). We found highly significant Aβ‐tau network integrations in AD vulnerable areas, as well as significant associations between those Aβ‐tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between Aβ and tau deposits in heteromodal areas of the human brain. They support a network‐based interaction between Aβ and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia.
We examined network interaction patterns within single positron emission tomography (PET) modality, such as Aß‐to‐Aß or Tau‐to‐Tau correlations, and between different PET modalities, such as Aß‐to‐Tau or Tau‐to‐Aß, at high‐resolution (voxel‐level) in cognitively normal older adults (CN), using a graph theory‐based analysis. We observed that the PET uptakes derived from Aß‐to‐Tau interdigitations were significantly associated with Alzheimer's Disease Assessment Scale‐Cognitive Subscale in AD vulnerable brain areas, a finding confirmed by our longitudinal investigation. Therefore, our work suggests the preceding contribution of network interactions between Aß and tau deposits to explain initial cognitive changes in CN prior to the conversion of dementia.
Databáze: OpenAIRE
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