Implications for Systemic Approaches to COVID-19: Effect Sizes of Remdesivir, Tocilizumab, Melatonin, Vitamin D3, and Meditation
| Autor: | J Adam Rindfleisch, Ryan Castle, Christine Tara Peterson, William C. Bushell, James Marzolf, Kimberly C. Brouwer, Michelle A. Williams, Paul J. Mills |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
medicine.medical_specialty meditation effect size Immunology Psychological intervention melatonin vitamin D Disease corticosteroids Melatonin chemistry.chemical_compound antivirals Tocilizumab Internal medicine Vitamin D and neurology Immunology and Allergy Medicine Original Research business.industry COVID-19 medicine.disease chemistry inflammation cytokine storm whole health Etiology Journal of Inflammation Research business Cytokine storm medicine.drug |
| Zdroj: | Journal of Inflammation Research |
| ISSN: | 1178-7031 |
| DOI: | 10.2147/jir.s323356 |
| Popis: | Introduction COVID-19 poses a chronic threat to inflammatory systems, reinforcing the need for efficient anti-inflammatory strategies. The purpose of this review and analysis was to determine the efficacy of various interventions upon the inflammatory markers most affected by COVID-19. The focus was on the markers associated with COVID-19, not the etiology of the virus itself. Methods Based on 27 reviewed papers, information was extracted on the effects of COVID-19 upon inflammatory markers, then the effects of standard treatments (Remdesivir, Tocilizumab) and adjunctive interventions (vitamin D3, melatonin, and meditation) were extracted for those markers. These data were used to approximate effect sizes for the disease or interventions via standardized mean differences (SMD). Results The data that were available indicated that adjunctive interventions affected 68.4% of the inflammatory markers impacted by COVID-19, while standard pharmaceutical medication affected 26.3%. Discussion Nonstandard adjunctive care appeared to have comparable or superior effects in comparison to Remdesivir and Tocilizumab on the inflammatory markers most impacted by COVID-19. Alongside standards of care, melatonin, vitamin D3, and meditation should be considered for treatment of SARS-COV-2 infection and COVID-19 disease. Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/2i2QG5lT0JI |
| Databáze: | OpenAIRE |
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