Increasing Fusion Rate Between 1 and 2 Years After Instrumented Posterolateral Spinal Fusion and the Role of Bone Grafting
| Autor: | A. Mechteld Lehr, Diederik H.R. Kempen, F. Cumhur Oner, Diyar Delawi, Eric A Hoebink, René M. Castelein, Job L C van Susante, Moyo C. Kruyt, Rebecca K. Stellato |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Facet (geometry) medicine.medical_specialty autograft Radiography medicine.medical_treatment Bone grafting Transplantation Autologous law.invention calcium phosphate intra-patient 03 medical and health sciences 0302 clinical medicine Randomized controlled trial fusion rate Double-Blind Method Putty law Randomized Trial Medicine Humans Orthopedics and Sports Medicine 030222 orthopedics Bone Transplantation Lumbar Vertebrae business.industry bone graft substitute interbody fusion Role Middle Aged intertransverse fusion posterolateral fusion Confidence interval Surgery surgical procedures operative Spinal Fusion Treatment Outcome Spinal fusion randomized controlled trial Bone Substitutes ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female Neurology (clinical) Fusion rate business 030217 neurology & neurosurgery |
| Zdroj: | Spine |
| ISSN: | 1528-1159 0362-2436 |
| Popis: | Supplemental Digital Content is available in the text Study Design. Two-year clinical and radiographic follow-up of a double-blind, multicenter, randomized, intra-patient controlled, non-inferiority trial comparing a bone graft substitute (AttraX® Putty) with autograft in instrumented posterolateral fusion (PLF) surgery. Objectives. The aim of this study was to compare PLF rates between 1 and 2 years of follow-up and between graft types, and to explore the role of bone grafting based on the location of the PLF mass. Summary of Background Data. There are indications that bony fusion proceeds over time, but it is unknown to what extent this can be related to bone grafting. Methods. A total of 100 adult patients underwent a primary, single- or multilevel, thoracolumbar PLF. After instrumentation and preparation for grafting, the randomized allocation side of AttraX® Putty was disclosed. The contralateral posterolateral gutters were grafted with autograft. At 1-year follow-up, and in case of no fusion at 2 years, the fusion status of both sides of each segment was blindly assessed on CT scans. Intertransverse and facet fusion were scored separately. Difference in fusion rates after 1 and 2 years and between grafts were analyzed with a Generalized Estimating Equations (GEE) model (P |
| Databáze: | OpenAIRE |
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