Polycystic Ovary Syndrome Phenotype Does Not Have Impact on Oocyte Morphology
Autor: | Geoffroy Robin, Laura M Keller, Audrey Uk, Camille Grysole, Hélène Behal, Didier Dewailly, Christine Decanter, Mauro S.B. Silva, Anne-Laure Barbotin |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Oocyte morphology QH471-489 Adolescent Morphology (biology) Biology ICSI Cohort Studies Andrology Young Adult Endocrinology Pregnancy medicine Humans Sperm Injections Intracytoplasmic Cell Shape Polycystic ovary syndrome Retrospective Studies Reproduction Research Pregnancy Outcome PCOS phenotypes Obstetrics and Gynecology Gynecology and obstetrics Morphologic scores Oocyte Polycystic ovary Phenotype medicine.anatomical_structure Reproductive Medicine Case-Control Studies RG1-991 Oocytes Female France Infertility Female Developmental Biology |
Zdroj: | Reproductive Biology and Endocrinology : RB&E Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022) |
Popis: | Purpose The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype. Methods We performed a retrospective cohort study in the IVF unit at the Lille University Medical Center (Lille, France) between 2006 and 2015. Oocyte morphology (fragmented first polar body, abnormal zona pellucida, large perivitelline space, material in perivitelline space, abnormal shape of oocyte, granular cytoplasm and intracytoplasmic vacuoles) was evaluated in PCOS women and according to different subgroup (depending on the presence or absence of the cardinal features polycystic ovarian morphology (PCOM), hyperandrogenism (HA), and oligo-anovulation (OA)). Results A total of 1496 metaphase II oocytes (n = 602 for phenotype A combining PCOM + HA + OA, n = 462 oocytes for phenotype C: PCOM + HA, and n = 432 for phenotype D: PCOM + OA) were assessed. The phenotypes A, C and D did not differ significantly with regard to the proportion of normal oocytes (adjusted percentages (95%CI): 35.2% (31.5 to 39.1%), 25.8% (21.9 to 29.9%) and 34.0% (29.7 to 38.6%), respectively: adjusted p = 0.13). Likewise, there were no significant intergroup differences in oocyte morphology. The ICSI outcome was not significantly associated with the PCOS phenotype. Conclusion The present study is the first to show that the PCOS phenotype (notably the presence vs. absence of OA and/or HA) is not significantly associated with the morphological quality of oocytes. |
Databáze: | OpenAIRE |
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