A Clinical Electrophysiological Study of Emotional Lability in Patients With Systemic Lupus Erythematosus
| Autor: | Boyd C.P. Ghosh, Howard Ring, Geoff Barrett, Richard Stratton, Stacey Rand, Jens M. Langosch, Michael R. Trimble, Colin Tench, David D'Cruz, Simeran Sharma |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Systemic disease Emotions Mismatch negativity Contingent Negative Variation P3a immune system diseases P3b Reaction Time medicine Humans Lupus Erythematosus Systemic Affective Symptoms skin and connective tissue diseases Depression (differential diagnoses) Analysis of Variance Lability Electroencephalography Middle Aged medicine.disease Psychiatry and Mental health Mood Acoustic Stimulation Immunology Evoked Potentials Auditory Anxiety Female Neurology (clinical) medicine.symptom Psychology Clinical psychology |
| Zdroj: | The Journal of Neuropsychiatry and Clinical Neurosciences. 20:201-209 |
| ISSN: | 1545-7222 0895-0172 |
| Popis: | Neuropsychiatric symptoms are well recognized in systemic lupus erythematosus (SLE), with depression and anxiety often reported. The authors’ clinical observations suggested emotional lability might also be a noteworthy symptom. In a consecutive series of systemic lupus erythematosus clinic attendees, the authors, therefore, measured depression, anxiety, and emotional lability. Additionally, based on reports linking emotional reactivity and transient mood changes to alterations in early attentional processes, the authors investigated event-related potential indices of preattentive and early orienting responses to auditory stimuli (N1, MMN, P3a and P3b). The authors observed that 15 of 32 participants with systemic lupus erythematosus had high lability scores and, comparing event-related potential measures between the high and low lability subgroups, noted that those with greater emotional lability demonstrated reduced response latencies in N1 and MMN paradigms. |
| Databáze: | OpenAIRE |
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