Syntheses of the Antibiotic Alkaloids Renierone, Mimocin, Renierol, Renierol Acetate, Renierol Propionate, and 7-Methoxy-1,6-dimethylisoquinoline-5,8-dione

Autor:	Tominari Choshi, Noriko Hiramatsu, Nagako Kuwabara, Hiroyuki Hayashi, Teppei Kumemura, Satoshi Hibino, Junko Nobuhiro
Rok vydání:	2004
Předmět:	chemistry.chemical_classification Electrocyclic reaction medicine.drug_class Organic Chemistry Antibiotics Regioselectivity Total synthesis General Medicine Biochemistry chemistry.chemical_compound chemistry Drug Discovery Propionate medicine Organic chemistry Isoquinoline Benzene
Zdroj:	ChemInform. 35
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200428206
Popis:	The total synthesis of renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5,8-dione was successfully achieved by the regioselective oxidation of 5-oxygenated isoquinoline. The synthetic method of the 5-oxygenated isoquinoline is based on the thermal electrocyclic reaction of 1-azahexatriene system involving the benzene 1,2-bond.
Databáze:	OpenAIRE
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