Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
| Autor: | Wei Li, Seo Young Yang, Hong Xu Li, Young Ho Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Epoxide hydrolase 2
Magnetic Resonance Spectroscopy Soluble epoxide hydrolase activity Stereochemistry Pharmaceutical Science 01 natural sciences Analytical Chemistry lcsh:QD241-441 soluble epoxide hydrolase activity lcsh:Organic chemistry Piper crocatum Drug Discovery Physical and Theoretical Chemistry IC50 Epoxide Hydrolases Molecular Structure biology Plant Extracts 010405 organic chemistry Chemistry Communication Spectrum Analysis Organic Chemistry Piperaceae biology.organism_classification 0104 chemical sciences Enzyme Activation Plant Leaves 010404 medicinal & biomolecular chemistry Solubility Chemistry (miscellaneous) Molecular Medicine phenolic Piper Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Molecules, Vol 24, Iss 3, p 489 (2019) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC50 value of 58.5 µM. |
| Databáze: | OpenAIRE |
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