CD8-positive lymphomatoid papulosis (type D): Some lesions may lack CD30 expression and overlap histologically with mycosis fungoides
| Autor: | Olivia C. Simo, Ahmed K. Alomari, Kristin Hoffmann, Simon J. Warren, Lawrence Aaron Mark |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms CD30 Biopsy Ki-1 Antigen Dermatology CD8-Positive T-Lymphocytes Clinical correlation Diagnosis Differential 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Mycosis Fungoides Lymphomatoid Papulosis immune system diseases hemic and lymphatic diseases medicine Humans Lymphomatoid papulosis Skin Mycosis fungoides integumentary system medicine.diagnostic_test business.industry Middle Aged medicine.disease Lymphoma 030220 oncology & carcinogenesis Female CD5 business CD8 |
| Zdroj: | International journal of dermatology. 58(7) |
| ISSN: | 1365-4632 |
| Popis: | Background CD8+ lymphomatoid papulosis is frequently indistinguishable histopathologically from primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma except for the expression of CD30. However, absent or weak expression of CD30 has been rarely reported in cases of CD8+ LyP. Objective We aim to study the clinical and pathologic features of cases of CD8+ LyP with no or minimal expression of CD30. Material and methods We identified all cases of CD8+ LyP diagnosed in our institution over a period of 10 years. Blinded comparison of clinical and histopathologic features of cases with and without CD30 expression was performed. Results Among seven cases (four patients) with definitive clinical and histopathologic diagnosis of CD8+ LyP, two cases (29%) had no expression of CD30. These two cases had more prominent epidermotropism, less epidermal ulceration, and less vascular damage relative to cases with CD30 expression and therefore resembled mycosis fungoides and type B LyP. CD5 and CD7 were frequently lost regardless of the CD30 status. Expression of cytotoxic markers was not different between the two groups. In the two cases with lack of CD30 expression, subsequent biopsies showed classic features of CD8+ LyP with strong expression of CD30. Conclusion CD8+ LyP with lack of expression of CD30 may have distinct histopathologic features that resemble mycosis fungoides and LyP type B. Clinically, they are indistinguishable from their CD30+ counterparts, signifying the importance of clinical correlation to avoid the erroneous diagnosis of lymphoma. Interval biopsies may be needed to establish a definitive diagnosis. |
| Databáze: | OpenAIRE |
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