Multidisciplinary Interventions in Motor Neuron Disease

Autor:	S. K. Oparah, U. E. Williams, E. E. Philip-Ephraim
Rok vydání:	2014
Předmět:	Pseudobulbar affect Palliative care Upper motor neuron business.industry Review Article Disease Motor neuron Riluzole medicine.anatomical_structure Neurology medicine Neurology (clinical) Spasticity medicine.symptom business Neuroscience Motor cortex medicine.drug
Zdroj:	Journal of Neurodegenerative Diseases
ISSN:	2090-8601 2090-858X
DOI:	10.1155/2014/435164
Popis:	Motor neuron disease is a neurodegenerative disease characterized by loss of upper motor neuron in the motor cortex and lower motor neurons in the brain stem and spinal cord. Death occurs 2–4 years after the onset of the disease. A complex interplay of cellular processes such as mitochondrial dysfunction, oxidative stress, excitotoxicity, and impaired axonal transport are proposed pathogenetic processes underlying neuronal cell loss. Currently evidence exists for the use of riluzole as a disease modifying drug; multidisciplinary team care approach to patient management; noninvasive ventilation for respiratory management; botulinum toxin B for sialorrhoea treatment; palliative care throughout the course of the disease; and Modafinil use for fatigue treatment. Further research is needed in management of dysphagia, bronchial secretion, pseudobulbar affect, spasticity, cramps, insomnia, cognitive impairment, and communication in motor neuron disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd3bd613d230327244d44c762b263a7 https://doi.org/10.1155/2014/435164 Zobrazit plný text záznamu Plný text