Real-world data of the association between quality of life using the EuroQol 5 Dimension 5 Level utility value and adverse events for outpatient cancer chemotherapy
| Autor: | Chiemi Hirose, Takuma Ishihara, Koichi Ohata, Nobuhisa Matsuhashi, Masashi Ishihara, Hirotoshi Iihara, Akio Suzuki, Takao Takahashi, Kumiko Okuda, Kumiko Sekiya, Masayo Naruse, Kazuhiro Yoshida, Hironori Fujii, Tadashi Sugiyama, Minako Nawa-Nishigaki, Hiroko Kato-Hayashi, Mika Kitahora |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Quality of life medicine.medical_specialty Adolescent Health Status Antineoplastic Agents Logistic regression Malaise Young Adult Japan Proportional odds logistic regression model Internal medicine Neoplasms Surveys and Questionnaires Outpatients Medicine Humans Adverse effect Aged Retrospective Studies Aged 80 and over business.industry Cancer Common Terminology Criteria for Adverse Events Chemotherapy-induced adverse events Retrospective descriptive study Odds ratio Middle Aged medicine.disease Chemotherapy regimen Oncology Female Original Article Outpatient cancer chemotherapy medicine.symptom business |
| Zdroj: | Supportive Care in Cancer |
| ISSN: | 1433-7339 |
| Popis: | Background Outpatient cancer chemotherapy may lead to improved quality of life (QOL) by allowing treatment to continue without impairing the social lives of patients compared with hospitalization. However, the occurrence of serious adverse events may cause a decline in QOL. We investigated the relationship between outpatient chemotherapy–induced adverse events and QOL. Methods A single-center retrospective descriptive study was conducted in patients who received outpatient chemotherapy at Gifu University Hospital (Gifu, Japan) between September 2017 and December 2018. The utility values of QOL, type and severity of adverse events, type of cancer, chemotherapy regimen, and other patient demographics were analyzed. Adverse events were graded according to the Common Terminology Criteria for Adverse Events, version 4.0. QOL was evaluated using the Japanese version of the EuroQol 5 Dimension 5 Level (EQ-5D-5L). Associations between the EQ-5D-5L utility value and serious adverse events were assessed using adjusted (age and sex) odds ratios obtained with a proportional odds logistic regression model. Results Data from 1008 patients who received 4695 chemotherapy cycles were analyzed. According to proportional odds logistic regression, the adverse events that significantly correlated with a decreased EQ-5D-5L utility value were malaise, edema of the limbs, peripheral neuropathy, pruritus, and dry skin. Based on the proportional odds logistic analysis, neither cancer type nor anticancer drugs were significantly correlated with the EQ-5D-5L utility value in patients who received chemotherapy. Pharmaceutical care for peripheral neuropathy significantly improved patients’ EQ-5D-5L utility value from 0.747 to 0.776 (P Conclusions Adverse events (i.e., peripheral neuropathy, malaise, and edema of the limbs) are significantly correlated with a decrease in QOL, regardless of the type of cancer or anticancer drugs used. Pharmaceutical care provided by pharmacists in collaboration with physicians may improve QOL. |
| Databáze: | OpenAIRE |
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