Clinical and Microbiological Outcomes of Serious Infections with Multidrug-Resistant Gram-Negative Organisms Treated with Tigecycline
| Autor: | Kara B. Anthony, Paul H. Edelstein, Neil O. Fishman, Ebbing Lautenbach, Leanne B. Gasink, Darren R. Linkin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Acinetobacter baumannii
Adult Male Microbiology (medical) medicine.drug_class Klebsiella pneumoniae Antibiotics Minocycline Microbial Sensitivity Tests Tigecycline beta-Lactamases Microbiology Minimum inhibitory concentration Enterobacteriaceae Drug Resistance Multiple Bacterial Gram-Negative Bacteria medicine Humans Aged Antibacterial agent Aged 80 and over biology business.industry Middle Aged biology.organism_classification Anti-Bacterial Agents Multiple drug resistance Treatment Outcome Infectious Diseases Female Gram-Negative Bacterial Infections business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 46:567-570 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/526775 |
| Popis: | Eighteen patients received tigecycline as treatment for infection due to multidrug-resistant gram-negative bacilli, including Acinetobacter baumannii and Klebsiella pneumoniae carbapenemase- and extended-spectrum beta-lactamase-producing Enterobacteriaceae. Pretherapy minimum inhibitory concentration values for tigecycline predicted clinical success. Observed evolution of resistance during therapy raises concern about routine use of tigecycline in treatment of such infections when other therapies are available. |
| Databáze: | OpenAIRE |
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