Renal nutrients uptake and brush-border membrane enzymes in cholesterol-fed guinea pigs
| Autor: | U C Garg, G. S. Sidhu, G. S. Dhaunsi, Rakesh Bhatnagar |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Brush border Hydrolases Endocrinology Diabetes and Metabolism Guinea Pigs Biology Kidney Biochemistry Aminopeptidase Cholesterol Dietary chemistry.chemical_compound Internal medicine medicine Animals Amino Acids Microvilli Reabsorption Cholesterol Sodium Biological Transport Glucose Endocrinology medicine.anatomical_structure chemistry Alkaline phosphatase Leucine Maltase |
| Zdroj: | Biochemical Medicine and Metabolic Biology. 36:179-185 |
| ISSN: | 0885-4505 |
| DOI: | 10.1016/0885-4505(86)90122-2 |
| Popis: | The effect of dietary cholesterol load on the reabsorption of nutrients and the enzyme and chemical characteristics of renal brush-border membrane (BBM) was evaluated in guinea pigs. The transport of D-glucose and amino acids into the renal BBM vesicles of experimental animals was significantly (P less than 0.001) decreased. Vmax of leucine aminopeptidase decreased without alteration in Km; however, both the Km and Vmax of alkaline phosphatase and maltase decreased in renal membrane in response to cholesterol load. The alterations in the chemical architecture of the membrane could possibly be responsible for the observed aberrations in the kidneys of cholesterol-fed animals. |
| Databáze: | OpenAIRE |
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