Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors
| Autor: | Douglas A. Lauffenburger, Douglas D. Richman, Hendrik Streeck, Matthew K. Schoen, Jishnu Das, Todd J. Suscovich, Susan J. Little, Amy W. Chung, Saheli Sadanand, Sophie Lane, Galit Alter, Davey M. Smith |
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| Přispěvatelé: | Massachusetts Institute of Technology. Anthropology Program, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Das, Jishnu, Chung, Amy H, Suscovich, Todd J, Lauffenburger, Douglas A, Alter, Galit |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Medizin HIV Infections Disease antibody-dependent effector functions HIV Antibodies Medical and Health Sciences Subclass Immunoglobulin G env Gene Products Cohort Studies 0302 clinical medicine Immunology and Allergy 2.1 Biological and endogenous factors Aetiology Neutralizing antibody Immunity Cellular biology env Gene Products Human Immunodeficiency Virus virus diseases Biological Sciences Infectious Diseases Disease Progression HIV/AIDS Disease Susceptibility Antibody Infection Human Immunodeficiency Virus Biotechnology Phagocytosis Immunology Viremia Article 03 medical and health sciences progressors Immunity Clinical Research Virology medicine Humans IgG subclasses Prevention IgG2 Psychology and Cognitive Sciences IgG3 controllers medicine.disease acute HIV 030104 developmental biology Good Health and Well Being Early Diagnosis HIV-specific IgG biology.protein Cellular 030215 immunology |
| Zdroj: | AIDS (London, England), vol 32, iss 4 PMC Sadanand, Saheli; Das, Jishnu; Chung, Amy W; Schoen, Matthew K; Lane, Sophie; Suscovich, Todd J; et al.(2018). Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors.. AIDS (London, England), 32(4), 443-450. doi: 10.1097/QAD.0000000000001716. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/521215kf |
| Popis: | Objective: Given the emerging appreciation for the role of antibody-dependent effector functions and IgG subclass distribution among spontaneous controllers of HIV, we sought to determine whether antibody-Associated features diverged in early HIV infection between patients who ultimately became controllers versus those who became progressors. Methods: IgG was purified from plasma from nine acutely infected patients who subsequently controlled HIV spontaneously (controllers) and 10 acutely infected individuals who did not control viremia (progressors). Antibody profiles were compared at weeks 4, 12, 24 and 48 postinfection. Levels of clade B gp120-specific, gp140-specific and gp41-specific IgG antibody subclasses were measured. In addition, gp120-specific antibody-dependent cellular phagocytosis, rapid fluorescent antibody-dependent cellular cytotoxicity and antibody-dependent cellular viral inhibition were all assessed. Results: Although no single antibody-related measurement was significantly associated with long-Term HIV control, combinations of antibody-Associated variables were able to accurately differentiate controllers and progressors. In contrast to controllers, progressors showed greater dynamic changes in gp120-specific subclass selection profiles, with increasing levels of Env-specific IgG2 antibodies and losses in Env-specific IgG3 antibodies. Moreover, progressors, but not controllers, lost antibody-dependent cellular viral inhibition function over time. Together, these results highlight changes in IgG subclass selection profiles in progressive, but not controlled, HIV infection. Conclusion: This study suggests that the temporal variation and maintenance of Env-specific IgG subclasses during acute HIV infection are predictive of eventual disease control. The maintenance of gp120-specific and gp140-specific IgG3 may contribute to control of disease in spontaneous controllers. Thus, strategies to induce stable IgG3 responses may preserve control of the viral reservoir. Massachusetts General Hospital. Executive Committee On Research (Fund for Medical Discovery) Harvard Center for AIDS Research (P30 AI060354-02) |
| Databáze: | OpenAIRE |
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