From Biomass-Derived p-Hydroxycinnamic Acids to Novel Sustainable and Non-Toxic Phenolics-Based UV-Filters: A Multidisciplinary Journey
| Autor: | Benjamin Rioux, Jeanne Combes, Jack M. Woolley, Natércia d. N. Rodrigues, Matthieu M. Mention, Vasilios G. Stavros, Florent Allais |
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| Přispěvatelé: | Agro-Biotechnologies Industrielles (ABI), AgroParisTech, Department of Chemistry [University of Warwick], University of Warwick [Coventry], BR, JC, MM, and FA thank the Grand Reims, the Conseil Départemental de la Marne, and the Grand Est region for financial support. The authors thank the support of the BoostCrop H2020 FetOpen grant (Grant Agreement 828753). BR, JC, MM, and FA thank the Agence Nationale de la Recherche (Grant Number ANR-17-CE07-0046) for funding. VS thanks the Royal Society for a Royal Society Industry Fellowship. NdNR thanks the support and funding received from the European Union’s Horizon 2020 research and innovation pro- gram under the Marie Skłodowska-Curie grant agreement No 844177—SUNNRL., ANR-17-CE07-0046,SINAPUV,(Bio)synthèse et étude des propriétés physico-chimiques et biologiques d'analogues du malate de sinapoyl: de nouvelles molécules anti-UV non-toxiques et biosourcées pour l'industrie cosmétique(2017), European Project: 828753,Boostcrop, European Project: 844177,SUNNRL |
| Jazyk: | angličtina |
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| Zdroj: | Frontiers in Chemistry Frontiers in Chemistry, 2022, 10, pp.886367. ⟨10.3389/fchem.2022.886367⟩ |
| ISSN: | 2296-2646 |
| DOI: | 10.3389/fchem.2022.886367 |
| Popis: | International audience; Although organic UV-filters are extensively used in cosmetics to protect consumers from the deleterious effects of solar UV radiation-exposure, they suffer from some major drawbacks such as their fossil origin and their toxicity to both humans and the environment. Thus, finding sustainable and non-toxic UV-filters is becoming a topic of great interest for the cosmetic industry. A few years ago, sinapoyl malate was shown to be a powerful naturally occurring UV-filter. Building on these findings, we decided to design and optimize an entire value chain that goes from biomass to innovative biobased and nontoxic lignin-derived UV-filters. This multidisciplinary approach relies on: 1) The production of phenolic synthons using either metabolite extraction from biomass or their bioproduction through synthetic biology/fermentation/in stream product recovery; 2) their functionalization using green chemistry to access sinapoyl malate and analogues; 3) the study of their UV-filtering activity, their photostability, their biological properties; and 4) their photodynamics. This mini-review aims at demonstrating that combining biotechnology, green chemistry, downstream process and photochemistry is a powerful approach to transform biomass and, in particular lignins, into high valueadded innovative UV-filters. |
| Databáze: | OpenAIRE |
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