Association of a Notch 3 gene polymorphism with migraine susceptibility
| Autor: | Rodney A. Lea, Saras Menon, J C MacMillan, Hannah Cox, Sharon Anne Quinlan, Larisa M. Haupt, Melissa Kuwahata, Lyn R. Griffiths |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Genotype Aura Migraine Disorders Population Single-nucleotide polymorphism Bioinformatics Polymerase Chain Reaction Polymorphism Single Nucleotide Notch 3 medicine Humans Genetic Predisposition to Disease CADASIL education Psychiatry Receptor Notch3 education.field_of_study Receptors Notch business.industry General Medicine medicine.disease Migraine with aura Migraine Neurology (clinical) Gene polymorphism medicine.symptom business |
| Zdroj: | Cephalalgia. 31:264-270 |
| ISSN: | 1468-2982 0333-1024 |
| Popis: | Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4, respectively, of the Notch 3 gene in migraine. Results: The first part of the study, in a population of 275 migraineurs and 275 control individuals, found a significant association between the C381T variant and migraine, specifically in migraine without aura (MO) sufferers. The G684A variant was also found to be significantly associated with migraine, specifically in migraine with aura (MA) sufferers. A follow-up study in 300 migraineurs and 300 control individuals did not show replicated association of the C381T variant with migraineurs. However, the G684A variant was again shown to be significantly associated with migraine, specifically with MA. Conclusion: Further investigation of the G684A variant and the Notch 3 gene is warranted to understand their role in migraine. |
| Databáze: | OpenAIRE |
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