A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties
| Autor: | Iury A. Paz, Aurideia P. de Sousa, Alda K.M. Holanda, Nilberto R.F. Nascimento, André F. Fernandes, Luiz Gonzaga de França Lopes, Javier Ellena, Eduardo H.S. Sousa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Infrared Chemistry General Chemistry Green-light 010402 general chemistry Photochemistry medicine.disease_cause Electrochemistry FARMACOLOGIA 01 natural sciences 0104 chemical sciences vasorelaxing activity NO photorelease metallodrugs medicine Reactivity (chemistry) Sodium nitroprusside nitrosyl complexes Ultraviolet Cysteine Visible spectrum medicine.drug |
| Zdroj: | Journal of the Brazilian Chemical Society v.28 n.11 2017 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ Journal of the Brazilian Chemical Society, Volume: 28, Issue: 11, Pages: 2117-2129, Published: NOV 2017 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The cis-[Ru(bpy)2(4-bzpy)(NO)](PF6)3 complex was prepared (4-bzpy = 4-benzoylpyridine), and characterized by UV-visible, infrared and nuclear magnetic resonance (NMR) spectroscopies and electrochemical techniques. The reaction with cysteine was preliminarily investigated, aiming to shed light on the potential biological mechanism for NO or HNO release mediated by thiols. Furthermore, photochemical behavior of cis-[Ru(bpy)2(4-bzpy)(NO)](PF6)3 was studied, where it was observed NO release upon ultraviolet, blue and green light irradiations. This latter long wavelength showed still good efficiency, which has not been reported for this type of complex. This feature is very important for a potential application in phototherapy. Additionally, vasorelaxant activity was investigated in rat-isolated aorta. This compound exhibited a greater maximum efficacy than sodium nitroprusside (SNP) as a blood vessel relaxant. Nevertheless, the EC50 for SNP (13.3 nmol L-1) was 52-fold smaller than the EC50 for cis-[Ru(bpy)2(4-bzpy)NO](PF6)3 (690 nmol L-1). Altogether, these results suggest this complex is a promising NO donor agent deserving further biological studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|