Neural mechanisms of social learning in the female mouse
| Autor: | Carl H Budlong, Ian G. Davison, Yuan Gao, Emily Durlacher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
QH301-705.5 Science Sensory system Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences pheromone 0302 clinical medicine Imprinting (psychology) Biology (General) learning General Immunology and Microbiology General Neuroscience Sensory memory social General Medicine 16. Peace & justice Social learning electrophysiology olfactory Olfactory bulb Electrophysiology 030104 developmental biology Sex pheromone Pheromone Medicine Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife, Vol 6 (2017) |
| Popis: | Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks. The cellular and synaptic correlates of pheromonal learning, however, remain unclear. We examined local circuit changes in the accessory olfactory bulb (AOB) using targeted ex vivo recordings of mating-activated neurons tagged with a fluorescent reporter. Imprinting led to striking plasticity in the intrinsic membrane excitability of projection neurons (mitral cells, MCs) that dramatically curtailed their responsiveness, suggesting a novel cellular substrate for pheromonal learning. Plasticity was selectively expressed in the MC ensembles activated by the stud male, consistent with formation of memories for specific individuals. Finally, MC excitability gained atypical activity-dependence whose slow dynamics strongly attenuated firing on timescales of several minutes. This unusual form of AOB plasticity may act to filter sustained or repetitive sensory signals. |
| Databáze: | OpenAIRE |
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