Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA)
| Autor: | Nicholas B. Larson, Christina L. Wassel, Hugues Sicotte, Michael P. Bancks, Suzette J. Bielinski, Naomi Q. Hanson, James S. Pankow, Paul A. Decker |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Diabetes risk Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Predictive Value of Tests Risk Factors Internal medicine Diabetes mellitus Ethnicity Medicine Humans Prospective Studies Aged Glycated Hemoglobin Sex Characteristics business.industry Hepatocyte Growth Factor Insulin Type 2 Diabetes Mellitus Middle Aged medicine.disease Insulin receptor complex Atherosclerosis United States Diabetes Mellitus Type 2 Socioeconomic Factors Female business Body mass index Biomarkers |
| Popis: | Background Hepatocyte growth factor (HGF) is a pleotropic factor posited to have metabolic homeostatic properties. The purpose of this study is to examine whether level of HGF is associated with the development of type 2 diabetes. Methods Data from the Multi-Ethnic Study of Atherosclerosis (MESA) were used to examine the prospective association between serum level of HGF and incident diabetes. Fasting HGF was measured at Exam 1 (2000-2002) in 5395 participants free from diabetes (61.5 ± 10.2 years old) and incidence of diabetes was determined at four subsequent follow-up exams over 12 years. Hazard ratios (HR) for incident diabetes were estimated according to 1 standard deviation (SD) unit increment of HGF (1 SD = 26 μg/l), before and after adjustment for age, sex, race/ethnicity, education, study center, smoking status, alcohol consumption, body mass index, waist circumference, fasting glucose and insulin, C-reactive protein, and interleukin-6 levels. Results A 1 SD increment of baseline HGF was associated with a 46% (95% CI = 1.37, 1.56) increased risk of diabetes before adjustment. After adjustment, diabetes risk per 1 SD increment of HGF was attenuated but remained significantly increased (HR = 1.21; 95% CI = 1.12, 1.32). Men had a significantly greater HR compared to women per equivalent increase of HGF (p-value for sex interaction = 0.04). There was no evidence of effect modification by race/ethnicity. Conclusions This study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism. |
| Databáze: | OpenAIRE |
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