Bacteroides gingivalis activates mouse spleen cells to produce a factor that stimulates resorptive activity of osteoclasts in vitro

Autor:	T. J. Marttjn Van Steenbergen, Cor A. Schipper, Johannes de Graaff, E.H. Burger, Adri A. Bom-van Noorloos
Rok vydání:	1986
Předmět:	Lymphokines Mouse Spleen Osteoclasts Biology biology.organism_classification Bone and Bones In vitro Bone resorption Cell biology Resorption Mice Periodontal disease Fetal mouse Immunology Animals Bacteroides Periodontics Bone Resorption Cells Cultured Spleen Bacteria
Zdroj:	Journal of Periodontal Research. 21:440-444
ISSN:	1600-0765 0022-3484
DOI:	10.1111/j.1600-0765.1986.tb01478.x
Popis:	Oral microorganisms are generally considered to be responsible for the initiation of inflammatory periodontal disease, but the mechanism by which they cause bone resorption has not yet been established. We report here that the periodontopathic bacterium B. gingivalis activates mouse spleen cells to produce a factor that strongly stimulates osteoclast-mediated mineral resorption. Resorption was measured as the release of 45Ca from prelabeled fetal mouse long bones in vitro.
Databáze:	OpenAIRE
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