Metabolic Conversion of N'-(2,4-dimethylphenyl)-N-methylformamidine Pesticide and the Analysis of the Metabolites
| Autor: | An Fengchun, Du Xiuying, Zhu Naikai, Xia Xijuan, Wang Shuqin |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Insecticides Chromatography Metabolite Health Toxicology and Mutagenesis Amidines Metabolism Urine General Medicine Pesticide Toxicology Pollution Rats Excretion chemistry.chemical_compound chemistry Toxicokinetics Animals Tissue Distribution Rats Wistar Quantitative analysis (chemistry) Amitraz |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 65:22-27 |
| ISSN: | 1432-0800 0007-4861 |
| Popis: | N'-(2,4-dimethylphenyl)-N-methylformamidine is a relatively new pesticide developed in China. The pesticide is similar to amitraz or N'-(2,4-dimet hylphenyl)-N-[(2,4-dimethylphenyl) imino]methyl-N-methylmethanimidamide. The metabolic fate of amitraz has been studied by Knowles (1981,1989). The present study describes the identification of N'- (2,4dimethylphenyl)-N-methylformamidine and its metabolites in rat livers by GC/FTIR and GUMS, and the quantitative analysis of the metabolites in the urine, blood, liver, kidney and spleen by GC-ECD at various times following the oral treatment with N'- (2,4dimethylphenyl)-N-methylformamidine. The absorption, distribution, degradation of the pesticide in rat body and excretion along with urine were discussed. |
| Databáze: | OpenAIRE |
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