Endotoxin impairs the human pacemaker current If

Autor:	B Pelzmann, K Zorn-Pauly, K Koidl, Henning Ebelt, Hendrik Schmidt, Ursula Mueller-Werdan, H Mächler, Petra Lang, Karl Werdan
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	business.industry Human heart Critical Care and Intensive Care Medicine Bioinformatics medicine.disease Sepsis Pacemaker potential Immunology Poster Presentation medicine Heart rate variability lipids (amino acids peptides and proteins) business Ionic Channels
Zdroj:	Critical Care
ISSN:	1466-609X 1364-8535
Popis:	Lipopolysaccharides (LPSs) trigger the development of sepsis by Gram-negative bacteria and cause a variety of biological effects on host cells including alterations in ionic channels. As heart rate variability is reduced in human sepsis and endotoxemia, we hypothesized that LPS affects the pacemaker current If in the human heart, which might – at least in part – explain this phenomenon.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc4f0bb8414b6177cee95e521fdc99b http://europepmc.org/articles/PMC4088619 Zobrazit plný text záznamu Full text from SpringerLink