Endotoxin impairs the human pacemaker current If
Autor: | B Pelzmann, K Zorn-Pauly, K Koidl, Henning Ebelt, Hendrik Schmidt, Ursula Mueller-Werdan, H Mächler, Petra Lang, Karl Werdan |
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Jazyk: | angličtina |
Rok vydání: | 2008 |
Předmět: | |
Zdroj: | Critical Care |
ISSN: | 1466-609X 1364-8535 |
Popis: | Lipopolysaccharides (LPSs) trigger the development of sepsis by Gram-negative bacteria and cause a variety of biological effects on host cells including alterations in ionic channels. As heart rate variability is reduced in human sepsis and endotoxemia, we hypothesized that LPS affects the pacemaker current If in the human heart, which might – at least in part – explain this phenomenon. |
Databáze: | OpenAIRE |
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