Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential
| Autor: | Xuejiao Sun, Maoping Song, Zhaoyang Li, Zhongke Sun, Lili Li, Chengwei Li, Xinqi Hao, Qingwei Hu, Juan Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases 030309 nutrition & dietetics Industrial and Manufacturing Engineering law.invention 03 medical and health sciences Probiotic 0404 agricultural biotechnology law Intervention (counseling) Animals Humans Medicine Intensive care medicine 0303 health sciences business.industry Probiotics nutritional and metabolic diseases Type 2 Diabetes Mellitus 04 agricultural and veterinary sciences General Medicine 040401 food science Diabetes Mellitus Type 2 business Microbial food cultures Food Science |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 60:670-683 |
| ISSN: | 1549-7852 1040-8398 |
| DOI: | 10.1080/10408398.2018.1547268 |
| Popis: | Type 2 diabetes mellitus (T2DM) has become one of the most prevalent diseases on earth and several treatments have been developed. However, the current intervention approaches have not been as effective as expected. One promising supplementary strategy is the use of probiotics through direct or indirect approaches. Probiotics are microbial food cultures conferring health-promoting properties. In this review, we summarized the current theories and mechanisms of T2DM intervention using probiotics and hypothesize that probiotics intervene T2DM during its onsetting, developing, and complicating. For the first time, we comprehensively analyzed T2DM intervention in animal models using both wide-type probiotics in different forms and using recombinant probiotics. Then, probiotic intervention in T2DM patients was reviewed and the main results were compared with that obtained from animal studies. Finally yet importantly, remaining questions that are important such as in which form and in which state, as well as the future potential of probiotic intervention in T2DM were discussed from a perspective of food microbiologists. In conclusion, probiotic intervention in T2DM is promising but there are still many important issues unsolved yet. Critical review of the advances, questions, and potential of probiotic intervention in T2DM promotes the development of this approach for further application in humans. |
| Databáze: | OpenAIRE |
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