Pickering w/o emulsions: drug release and topical delivery

Autor: Hanna Mouaziz, Justyna Frelichowska, Yves Chevalier, J.P. Valour, Jocelyne Pelletier, Marie-Alexandrine Bolzinger
Přispěvatelé: Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2008
Předmět:
Swine
Administration
Topical
Chemistry
Pharmaceutical
Skin Absorption
Kinetics
Pharmaceutical Science
02 engineering and technology
In Vitro Techniques
010402 general chemistry
01 natural sciences
Dosage form
Permeability
Surface-Active Agents
Adsorption
Drug Stability
Caffeine
Stratum corneum
medicine
Animals
[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
Particle Size
ComputingMilieux_MISCELLANEOUS
Dosage Forms
Drug Carriers
Chromatography
integumentary system
Chemistry
ACL
Water
[CHIM.MATE]Chemical Sciences/Material chemistry
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Permeation
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Silicon Dioxide
Pickering emulsion
0104 chemical sciences
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry
[CHIM.POLY]Chemical Sciences/Polymers
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
medicine.anatomical_structure
Chemical engineering
Emulsion
Emulsions
Particle size
0210 nano-technology
Oils
Zdroj: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2009, 368 (1-2), pp.7-15. ⟨10.1016/j.ijpharm.2008.09.057⟩
International Journal of Pharmaceutics, Elsevier, 2009, 368 (1-2), pp.7-15
ISSN: 1873-3476
0378-5173
DOI: 10.1016/j.ijpharm.2008.09.057⟩
Popis: The skin absorption from Pickering emulsions as a new dosage form was investigated for the first time. Pickering emulsions are stabilized by adsorbed solid particles instead of emulsifier molecules. They are promising dosage forms that significantly differ from classical emulsions within several features. The skin permeation of a hydrophilic model penetrant (caffeine) was investigated from a w/o Pickering emulsion and compared to a w/o classical emulsion stabilized with an emulsifier. Both emulsions had the same composition and physicochemical properties in order to focus on the effect of the interfacial layer on the drug release and skin absorption processes. The highest permeation rates were obtained from the Pickering emulsion with a pseudo-steady state flux of 25 microg cm(-2)h(-1), threefold higher than from a classical emulsion (9.7 microg cm(-2)h(-1)). After 24h exposure, caffeine was mostly in the receptor fluid and in the dermis; cumulated amounts of caffeine were higher for the Pickering emulsion. Several physicochemical phenomena were investigated for clearing up the mechanisms of enhanced permeation from the Pickering emulsion. Among them, higher adhesion of Pickering emulsion droplets to skin surface was disclosed. The transport of caffeine adsorbed on silica particles was also considered relevant since skin stripping showed that aggregates of silica particles entered deeply the stratum corneum.
Databáze: OpenAIRE
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