Dementia in idiopathic Parkinson's disease. Variables associated with its occurrence in 203 patients
| Autor: | Hava Sroka, Teresita S. Elizan, H. Smith, H. Maker, Melvin D. Yahr |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Neurology Time Factors Neurological examination Disease Neuropsychological Tests Pathogenesis Degenerative disease Tremor medicine Dementia Humans Biological Psychiatry Aged Movement Disorders medicine.diagnostic_test Proportional hazards model business.industry Age Factors Parkinson Disease Middle Aged medicine.disease nervous system diseases Dihydroxyphenylalanine Psychiatry and Mental health Physical therapy Population study Regression Analysis Female Neurology (clinical) business |
| Zdroj: | Journal of neural transmission. 65(3-4) |
| Popis: | A series of 203 patients with primary Parkinson's disease treated with L-DOPA, with adequate neurological documentation of mental status at serial intervals during their illness, constitutes the study population. Based on the results of the latest neurological examination, slightly less than one-third (29%) had mental impairment assessed as neurologically significant. Of the eleven clinical variables analysed (Cox regression analysis) for potential influence on the occurrence of an organic mental syndrome, four had a statistically significant effect: (1) the stage of disease at initial neurological examination; (2) the occurrence of acute confusional states; (3) the years of Parkinson's prior to L-DOPA; and (4) the total duration of L-DOPA therapy. The pathogenesis of dementia in this subgroup of Parkinson's disease is discussed. |
| Databáze: | OpenAIRE |
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