Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts

Autor:	Hidekatsu Yoshioka, Noritaka Matsuo, Hideki Hokazono, Takako Sasaki, Eriko Uehara
Rok vydání:	2017
Předmět:	0106 biological sciences 0301 basic medicine Matrix (biology) Bioinformatics 01 natural sciences Applied Microbiology and Biotechnology Biochemistry Collagen Type I Analytical Chemistry 03 medical and health sciences 010608 biotechnology Gene expression Humans RNA Messenger Molecular Biology Gene Pcr analysis gamma-Aminobutyric Acid Skin chemistry.chemical_classification Chemistry Organic Chemistry General Medicine Fibroblasts Molecular biology Collagen Type I alpha 1 Chain Collagen type I alpha 1 030104 developmental biology Enzyme Gene Expression Regulation Matrix Metalloproteinase 1 Type I collagen Biotechnology Skin elasticity
Zdroj:	Bioscience, Biotechnology, and Biochemistry. 81:376-379
ISSN:	1347-6947 0916-8451
Popis:	We examined the effects of GABA on type I collagen gene expression in normal human dermal fibroblasts. Real-time PCR analysis indicated GABA increased the level of type I collagen transcripts, and suppressed the expression of matrix metalloproteinase-1, which is a collagen-degrading enzyme. These results suggest GABA improves the skin elasticity by regulating type I collagen expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc06d259ab882ba9c08e03f2ed14b62 https://doi.org/10.1080/09168451.2016.1238296 Zobrazit plný text záznamu