Semliki Forest virus envelope proteins function as proton channels
| Autor: | Adames Omar, Christoph Kempf, Andreas Morell, Pia Jentsch, Andreas Schlegel |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Proton
viruses Molecular Sequence Data Biophysics Alphavirus Semliki Forest virus Biochemistry Ion Channels Virus Viral Envelope Proteins Viral envelope Aedes Animals Amino Acid Sequence Molecular Biology Ion transporter biology Cell Biology Hydrogen-Ion Concentration biology.organism_classification Semliki forest virus Clone Cells Ectodomain Togaviridae Protons |
| Zdroj: | Bioscience Reports. 11:243-255 |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | It has been shown that isolated nucleocapsids of Semliki Forest virus (SFV) contract upon low pH exposure (Soederlund et al., 1972). This contraction of the nucleocapsids has been used as an indicator to demonstrate that the spike proteins of SFV can translocate protons into the interior of the virus particle upon low pH (5.8) exposure. Spikeless virus particles obtained after bromelain digestion, which were used as a control, did not translocate protons. This implies that the ectodomain of the spike plays a crucial role for the proton translocation. |
| Databáze: | OpenAIRE |
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