Micronuclei assay of exfoliated oral buccal cells: Means to assess the nuclear abnormalities in different diseases
| Autor: | Bina Kashyap, Padala Sridhar Reddy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty exfoliated buccal cells DNA damage Biopsy Cytodiagnosis Buccal swab Biology medicine.disease_cause Buccal mucosa complex mixtures lcsh:RC254-282 genotoxic Neoplasms Occupational Exposure medicine Animals Humans Radiology Nuclear Medicine and imaging Radiation Injuries Carcinogen Micronuclei Chromosome-Defective Cell Nucleus Micronucleus Tests Mouth Mucosa General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lifestyle factors Oncology Neoplasms diagnosis micronuclei Micronucleus test Carcinogens Genotoxicity DNA Damage Mutagens |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 8, Iss 2, Pp 184-191 (2012) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | The micronuclei assay (MA) in exfoliated buccal cells is an innovative genotoxicity technique, which holds promise for the study of epithelial carcinogens. Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. This article reviews the MN assay with respect to oral buccal mucosa, which has been used since the 1980s to demonstrate cytogenetic effects of environmental and occupational exposures, lifestyle factors, dietary deficiencies, and different diseases along with the characteristics of micronuclei and other nuclear abnormalities. |
| Databáze: | OpenAIRE |
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