Retiro precoz de esteroides en la inmunosupresión del trasplante renal pediátrico
| Autor: | Luis Contreras M, Jorge Godoy L, Angela Delucchi B, Eugenio Rodríguez S, Marcela Valenzuela A, Erwin Buckel B, Mario Ferrario B, Jorge Rodríguez H, Gloria González G, Francisco Cano Sch, Ana María Lillo D, José Luis Guerrero G, Gabriel Cavada Ch |
|---|---|
| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Basiliximab business.industry medicine.medical_treatment Renal function Azathioprine Immunosuppression General Medicine Gastroenterology Tacrolimus Surgery Transplantation Kidney transplantation Internal medicine medicine Transplantation conditionning Prospective cohort study business Lipid profile medicine.drug |
| Zdroj: | Revista médica de Chile v.134 n.11 2006 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Background: Cardiovascular risk, growth failure and the new immunosuppressive drugs, have encouraged steroid withdrawal or total avoidance with promising results in renal transplant (Tx) immunosuppression. Aim: To evaluate a new immunosuppressor protocol with early withdrawal of steroids in pediatric kidney transplant. Patients and methods: Prospective study in pediatric patients older than 1 year and low immunological risk. Group A (n =28): steroids in decreasing doses until day 7 post Tx, tacrolimus (FK) and micophenolate mofetil (MMF). Group B (n =28) control: steroids, cyclosporine and azathioprine or steroids, FK and MMF. In both groups the induction therapy included basiliximab. Anthropometric and biochemical variables (renal function, lipid profile, hematological, blood glucose and acid-base equilibrium), acute rejection and CMV infection, were evaluated. Mean values and variations for continuous variables were calculated at months 1, 6, 12 and 18. Results: Two children were withdrawn before month 2, one had an untreatable diarrhea and the second died due to Aspergillus septicemia. Mean values at months 1, 6, 12 and 18 for groups A and B: Creatinine clearence (ml/min): 85.4 vs 89; 79.9 vs 83; 89 vs 80; 79.8 vs 80.6 (p: ns); hematocrit (%): 28.8 vs 30.4; 31.7 vs 34.4; 34.4; 32.4 vs 34.8; 34.4 vs 35.5 (p: ns). Total cholesterol (mg/dl): 151 vs 206; 139 vs 174; 138 vs 186; 140 vs 180 (p |
| Databáze: | OpenAIRE |
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