Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus
| Autor: | M Shenoy, J E Craighead, Subramaniam Sriram, David J. Topham, Adekunle M. Adesina |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
CD4-Positive T-Lymphocytes
Encephalomyelitis Immunology Central nervous system Inflammation Viremia Biology Antibodies Viral Lymphocyte Activation T-Lymphocytes Regulatory Microbiology Virus Leukocyte Count Mice Immune system Virology medicine Animals Encephalomyocarditis virus Mice Inbred BALB C Antibodies Monoclonal medicine.disease medicine.anatomical_structure Insect Science biology.protein Female medicine.symptom Antibody CD8 Poliomyelitis Research Article |
| Zdroj: | Journal of Virology. 65:3238-3245 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.65.6.3238-3245.1991 |
| Popis: | Infection of female BALB/c mice with encephalomyocarditis virus results in the development of a paralytic syndrome in 7 to 10 days postinoculation. Previous studies had suggested the involvement of an immune component in the development of central nervous system pathology. We have examined the effects of T-cell depletion on the development of polioencephalitis (neuronal necrosis and inflammation of the brain and brain stem) and the relative contribution of the CD4+ and CD8+ subsets following the establishment of viremia. We show that monoclonal antibody depletion of T cells is effective in the reduction of polioencephalitis when given prior to viral inoculation. However, administration of the antibodies 12 h or more after viral inoculation failed to alter the development of polioencephalitis or encephalomyelitis. We conclude that T cells are involved in the development of central nervous system disease during the initial stages of infection but are not responsible for the later progression of disease. |
| Databáze: | OpenAIRE |
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