Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord
| Autor: | Audrey Harris, Gauhar Masgutova, Frédéric Clotman, Lynn M. Corcoran, Benvenuto Jacob, María Hidalgo-Figueroa, Mathilde Toch, Amandine Collin, Cédric Francius |
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| Přispěvatelé: | UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gene isoform Interneuron embryonic spinal cord Biology lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Biological neural network Distribution (pharmacology) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Transcription factor 030304 developmental biology Original Research 0303 health sciences Spinal interneuron neuronal migration Onecut Embryogenesis differentiation V2 interneurons Spinal cord 030104 developmental biology medicine.anatomical_structure Pou2f2 Neuroscience 030217 neurology & neurosurgery Onecut Transcription Factors |
| Zdroj: | Frontiers in Cellular Neuroscience, Vol. 13, no.184, p. 1 (2019) Frontiers in Cellular Neuroscience, Vol 13 (2019) Frontiers in Cellular Neuroscience |
| DOI: | 10.1101/413054 |
| Popis: | Acquisition of proper neuronal identity and position is critical for the formation of neural circuits. In the embryonic spinal cord, cardinal populations of interneurons diversify into specialized subsets and migrate to defined locations within the spinal parenchyma. However, the factors that control interneuron diversification and migration remain poorly characterized. Here, we show that the Onecut transcription factors are necessary for proper diversification and distribution of the V2 interneurons in the developing spinal cord. Furthermore, we uncover that these proteins restrict and moderate the expression of spinal isoforms ofPou2f2, a transcription factor known to regulate B-cell differentiation. By gain- or loss-of-function experiments, we show that Pou2f2 contribute to regulate the position of V2 populations in the developing spinal cord. Thus, we uncovered a genetic pathway that regulates the diversification and the distribution of V2 interneurons during embryonic development.Significance statementIn this study, we identify the Onecut and Pou2f2 transcription factors as regulators of spinal interneuron diversification and migration, two events that are critical for proper CNS development. |
| Databáze: | OpenAIRE |
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