Analysis of Survival After Liver Transplantation in Galicia, Spain
| Autor: | Mónica Rodríguez-Martínez, José Ramón González-Juanatey, S. Tomé Martı́nez de Rituerto, M. Delgado Blanco, E. Varo Pérez, C. Fernández Sellés, D. Sánchez-Guisande Jack, M. Gómez Gutiérrez, Fernando Otero-Raviña |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Alcoholic liver disease medicine.medical_specialty Cirrhosis Adolescent medicine.medical_treatment Liver transplantation Infections Liver disease Postoperative Complications Risk Factors Cause of Death Internal medicine medicine Humans De novo malignancy Child Retrospective Studies Cause of death Heart Failure Transplantation business.industry Graft Survival Age Factors Infant Middle Aged medicine.disease Tissue Donors Liver Transplantation Surgery Survival Rate Spain Child Preschool Heart failure Female business |
| Zdroj: | Transplantation Proceedings. 37:3913-3915 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2005.09.166 |
| Popis: | Background Transplantation is the treatment of choice for many patients with end-stage liver disease. We evaluated the results of liver transplantation in Galicia, an autonomous community in Northwest Spain. Methods We analyzed 452 patients and 490 grafts from 1996 to 2000 for causes of loss with respect to recipient and donor variables using the actuarial method, Kaplan-Meier curves, log-rank test, and Cox proportional risks model. Results The overall graft survival was 77% and 64% at 1 and 5 years, respectively; while that of the patients was 83% and 69%. The risk factors for graft loss were donation in heart failure (HR = 4.91, CI:2.51–9.61); donor age (HR = 1.70, CI:1.01–2.85 between 40 and 60 years; HR = 2.37, CI:1.37–4.10 in those over 60 years, as compared to patients under 40); urgent transplant (HR = 3.95, CI:2.07–7.54); and transplant due to acute liver failure (HR = 3.53, CI:1.72–7.25) as compared to alcoholic cirrhosis. For patient death the risk factors were age of recipient over 60 years, compared to those under 40 (HR = 2.42, CI:1.11–5.28); foreign place of origin (HR = 2.02, CI:1.14–3.59); transplant due to viral cirrhosis (HR = 1.76, CI:1.03–3.02) and transplant due to acute liver failure (HR = 4.62, CI:2.12–10.06), as compared to alcoholic cirrhosis; urgent transplant (HR = 2.65, CI:1.48–4.72), and age of donor over 60 years, as compared to those under 40 (HR = 2.65, CI:1.48–4.72). Infections were the principal cause of death (45%), mostly in the first month (72%); while after the first year, 74% were due to recurrence of the primary disease and de novo malignancy. Conclusions Graft and patient survivals were comparable to international registries. The donor characteristics had a greater influence on graft survival than on patient survival. |
| Databáze: | OpenAIRE |
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