The Effectiveness of Intraocular Methotrexate in the Treatment of Posterior Uveitis in Behçet’s Disease Patients Compared to Retrobulbar Steroids Injection
| Autor: | Heba A. El Gendy, Hazem Effat Haroun, Hala Ahmed Raafat Youssef, Hossam Mahmoud Bakir, Tamer A. Gheita, Khalil Hm |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Triamcinolone acetonide genetic structures Article Subject Behcet's disease Group A Group B 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Ophthalmology medicine 030203 arthritis & rheumatology business.industry medicine.disease eye diseases Surgery Posterior segment of eyeball lcsh:RE1-994 Posterior uveitis Male patient Clinical Study 030221 ophthalmology & optometry Methotrexate sense organs business medicine.drug |
| Zdroj: | Journal of Ophthalmology Journal of Ophthalmology, Vol 2016 (2016) |
| ISSN: | 2090-0058 2090-004X |
| Popis: | Aim of Work. To evaluate the efficacy of intravitreal methotrexate (MTX) compared to retrobulbar triamcinolone acetonide (TAA), in controlling posterior segment involvement and inducing remissions among Behçet’s disease (BD) patients.Study Design. This is a cross-sectional nonrandomized comparative study.Patients and Methods. 31 adult BD male patients with a mean disease duration of 5.45 years who presented with bilateral posterior segment involvement were included. Each patient received intravitreal injection of 400 μg/0.1 mL (MTX) for the right eye (Group A) and 1 mL of retrobulbar 40 mg/mL TAA for the left eye (Group B).Results. 90% of eyes showed complete improvement of anterior chamber reaction, whereas an improvement in vitreous activity in 77% with no significant differences between both groups (p≤0.1). BCVA improved in 77.4% eyes (Group A) compared to 87.1% (Group B) (p≤0.4). Relapses were noted in 11 eyes (35.5%), in group A, with the mean duration of remission being 19.1 weeks ± 2.13 compared to7.35±2.8in 20 eyes (64.5%) in group B (p≤0.1).Conclusion. No statistical differences were found between both treatment modalities; however, based on clinical observations, intravitreal MTX may ensure better control of inflammatory reaction and may encourage longer remission as compared to retrobulbar TAA in BD patients. |
| Databáze: | OpenAIRE |
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