Specific Kinematics and Motor-Related Neurons for Aversive Chemotaxis in Drosophila
| Autor: | Christopher Potter, Alexander Y. Katsov, Thomas R. Clandinin, Liqun Luo, Xiaojing J. Gao, Marion Silies, Daryl M. Gohl |
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| Rok vydání: | 2013 |
| Předmět: |
Kinematics
Motor Activity Optogenetics Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Animals Drosophila 030304 developmental biology Motor Neurons 0303 health sciences biology Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Chemotaxis Motor control Anatomy Olfactory Perception biology.organism_classification Attraction Biomechanical Phenomena Drosophila melanogaster Ventral nerve cord Cues General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Biology. 23(13):1163-1172 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2013.05.008 |
| Popis: | Summary Background: Chemotaxis, the ability to direct movements according to chemical cues in the environment, is important for the survival of most organisms. The vinegar fly, Drosophila melanogaster, displays robust olfactory aversion and attraction, but how these behaviors are executed via changes in locomotion remains poorly understood. In particular, it is not clear whether aversion and attraction bidirectionally modulate a shared circuit or recruit distinct circuits for execution. Results:Using a quantitative behavioral assay, we determined that both aversive and attractive odorants modulate the initiation and direction of turns but display distinct kinematics. Using genetic tools to perturb these behaviors, we identified specific populations of neurons required for aversion, but not for attraction. Inactivation of these populations of cells affected the completion of aversive turns, but not their initiation. Optogenetic activation of the same populations of cells triggered a locomotion pattern resembling aversive turns. Perturbations in both the ellipsoid body and the ventral nerve cord, two regions involved in motor control, resulted in defects in aversion. Conclusions: Aversive chemotaxis in vinegar flies triggers ethologically appropriate kinematics distinct from those of attractive chemotaxis and requires specific motor-related neurons. |
| Databáze: | OpenAIRE |
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