Clinical factors related to brain structure in HIV: the CHARTER study

Autor: Jernigan, Terry L, Archibald, Sarah L, Fennema-Notestine, Christine, Taylor, Michael J, Theilmann, Rebecca J, Julaton, Michelle D, Notestine, Randy J, Wolfson, Tanya, Letendre, Scott L, Ellis, Ronald J, Heaton, Robert K, Gamst, Anthony C, Franklin, Donald R, Clifford, David B, Collier, Ann C, Gelman, Benjamin B, Marra, Christina, McArthur, Justin C, McCutchan, J Allen, Morgello, Susan, Simpson, David M, Grant, Igor, CHARTER Group
Rok vydání: 2011
Předmět:
CD4-Positive T-Lymphocytes
Male
AIDS Dementia Complex
medicine.medical_treatment
HIV Infections
Hepacivirus
Cerebrospinal fluid
Antiretroviral Therapy
Highly Active
Medicine
Viral
Longitudinal Studies
Cerebral Cortex
virus diseases
Immunosuppression
Hepatitis C
Viral Load
Middle Aged
Magnetic Resonance Imaging
Subcortical gray matter
Infectious Diseases
Mental Health
medicine.anatomical_structure
Anti-Retroviral Agents
Neurology
Medical Microbiology
6.1 Pharmaceuticals
Neurological
Coinfection
RNA
Viral
HIV/AIDS
Female
medicine.symptom
Infection
Viral load
MRI
Adult
Clinical Sciences
Antiretroviral Therapy
Neuroimaging
Brain damage
Immunospupression
Article
White matter
Cellular and Molecular Neuroscience
Clinical Research
Virology
Humans
Highly Active
Aged
business.industry
Neurosciences
HIV
Evaluation of treatments and therapeutic interventions
medicine.disease
CD4 Lymphocyte Count
Brain Disorders
Good Health and Well Being
CHARTER Group
Immunology
RNA
Neurology (clinical)
business
Zdroj: Journal of neurovirology, vol 17, iss 3
Jernigan, TL; Archibald, SL; Fennema-Notestine, C; Taylor, MJ; Theilmann, RJ; Julaton, MD; et al.(2011). Clinical factors related to brain structure in HIV: The CHARTER study. Journal of NeuroVirology, 17(3), 248-257. doi: 10.1007/s13365-011-0032-7. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2vd5m2t7
ISSN: 1538-2443
1355-0284
DOI: 10.1007/s13365-011-0032-7
Popis: Despite the widening use of combination antiretroviral therapy (ART), neurocognitive impairment remains common among HIV-infected (HIV+) individuals. Associations between HIV-related neuromedical variables and magnetic resonance imaging indices of brain structural integrity may provide insight into the neural bases for these symptoms. A diverse HIV+ sample (n=251) was studied through the CNS HIV Antiretroviral Therapy Effects Research initiative. Multi-channel image analysis produced volumes of ventricular and sulcal cerebrospinal fluid (CSF), cortical and subcortical gray matter, total cerebral white matter, and abnormal white matter. Cross-sectional analyses employed a series of multiple linear regressions to model each structural volume as a function of severity of prior immunosuppression (CD4 nadir), current CD4 count, presence of detectable CSF HIV RNA, and presence of HCV antibodies; secondary analyses examined plasma HIV RNA, estimated duration of HIV infection, and cumulative exposure to ART. Lower CD4 nadir was related to most measures of the structural brain damage. Higher current CD4, unexpectedly, correlated with lower white and subcortical gray and increased CSF. Detectable CSF HIV RNA was related to less total white matter. HCV coinfection was associated with more abnormal white matter. Longer exposure to ART was associated with lower white matter and higher sulcal CSF. HIV neuromedical factors, including lower nadir, higher current CD4 levels, and detectable HIV RNA, were associated with white matter damage and variability in subcortical volumes. Brain structural integrity in HIV likely reflects dynamic effects of current immune status and HIV replication, superimposed on residual effects associated with severe prior immunosuppression. © Journal of NeuroVirology, Inc. 2011.
Databáze: OpenAIRE
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