Variations in cell-mediated immunity to Trypanosoma cruzi during experimental Chagas' disease
| Autor: | J. R. Maleckar, F. Kierszenbaum |
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| Rok vydání: | 1983 |
| Předmět: |
Chagas disease
Trypanosoma cruzi 030231 tropical medicine T-Lymphocytes Regulatory 03 medical and health sciences Mice 0302 clinical medicine Antigen Immunity 030225 pediatrics medicine Macrophage Animals Chagas Disease Hypersensitivity Delayed Antigens Immunodeficiency Immunity Cellular biology Macrophages Cell Migration Inhibition biology.organism_classification medicine.disease Infectious Diseases Immunology Mice Inbred CBA Parasitology Macrophage migration inhibitory factor Female |
| Zdroj: | Annals of tropical medicine and parasitology. 77(3) |
| ISSN: | 0003-4983 |
| Popis: | Mice infected with bloodstream forms of Trypanosoma cruzi were found unable to respond significantly to subcutaneous stimulation with parasite antigens with a delayed-type hypersensitivity skin reaction during the acute phase of the disease. Consistent with this observation, peritoneal cells collected from infected mice during the acute period were unresponsive in in vitro assays for production of macrophage migration inhibitory factor. By contrast, both specific skin reactivity and significant inhibition of macrophage migration were noted during the chronic stage, i.e. when parasitaemias were on the decline or undetectable and mortality no longer occurred. Given the similarity between the kinetic changes in cell-mediated immunity monitored by in vivo tests and their in vitro correlate, the latter was used to explore the possible role of suppressor T cells in the causation of immunodeficiency recorded during the acute phase. Peritoneal cells from acutely infected animals failed to alter production of macr... |
| Databáze: | OpenAIRE |
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