Stromal cells in the pathogenesis of inflammatory bowel disease
| Autor: | Lukas J. A. C. Hawinkels, Marieke C. Barnhoorn, Gerhard Rogler, Michael Scharl, S K Hakuno, Ramona S Bruckner |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Stromal cell
610 Medicine & health MSCs Disease Mesenchymal Stem Cell Transplantation Inflammatory bowel disease Reviews Articles Arthritis Rheumatoid Pathogenesis Immune system Cancer-Associated Fibroblasts Stroma inflammatory bowel disease Neoplasms fibroblasts stroma Animals Homeostasis Humans Medicine 2715 Gastroenterology Intestinal Mucosa Stromal cells AcademicSubjects/MED00260 Wound Healing Gastrointestinal tract business.industry Mesenchymal stem cell Gastroenterology General Medicine Inflammatory Bowel Diseases medicine.disease digestive system diseases Gastrointestinal Tract 10219 Clinic for Gastroenterology and Hepatology Immunology business |
| Zdroj: | Journal of Crohn's and Colitis, 14(7), 995-1009. OXFORD UNIV PRESS Journal of Crohn's & Colitis |
| Popis: | Up till now, research on inflammatory bowel disease [IBD] has mainly been focused on the immune cells present in the gastrointestinal tract. However, recent insights indicate that stromal cells also play an important and significant role in IBD pathogenesis. Stromal cells in the intestines regulate both intestinal epithelial and immune cell homeostasis. Different subsets of stromal cells have been found to play a role in other inflammatory diseases [e.g. rheumatoid arthritis], and these various stromal subsets now appear to carry out also specific functions in the inflamed gut in IBD. Novel potential therapies for IBD utilize, as well as target, these pathogenic stromal cells. Injection of mesenchymal stromal cells [MSCs] into fistula tracts of Crohn’s disease patients is already approved and used in clinical settings. In this review we discuss the current knowledge of the role of stromal cells in IBD pathogenesis. We further outline recent attempts to modify the stromal compartment in IBD with agents that target or replace the pathogenic stroma. |
| Databáze: | OpenAIRE |
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