Disrupted functional connectome in antisocial personality disorder
Autor: | Tao Wang, Jian Liao, Dewen Hu, Hui Shen, Weixiong Jiang, Huasheng Liu, Feng Shi, Celina Shen, Wei Wang, Dinggang Shen |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Cognitive Neuroscience Rest Article 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine Neuroimaging mental disorders Neural Pathways medicine Control network Connectome Functional connectome Humans Radiology Nuclear Medicine and imaging Modularity (networks) medicine.diagnostic_test Antisocial personality disorder Neuropsychology Brain Cognition Antisocial Personality Disorder Criminals medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Neurology Neurology (clinical) Psychology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
Popis: | Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD. |
Databáze: | OpenAIRE |
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