Transcutaneous Slowly Depolarizing Currents Elicit Pruritus in Patients with Atopic Dermatitis
| Autor: | Elke Weisshaar, Roman Rukwied, Martin Schmelz, Mark Schnakenberg, Hans Jürgen Solinkski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Eczema c-nociceptor Stimulation Dermatology Dermatitis Atopic lcsh:Dermatology otorhinolaryngologic diseases medicine Humans In patient itch skin and connective tissue diseases Antipruritic Skin business.industry Pruritus transcutaneous electrical stimulation Depolarization Transcutaneous Electrical Stimulation Antipruritics General Medicine Atopic dermatitis lcsh:RL1-803 medicine.disease Peripheral business medicine.drug |
| Zdroj: | Acta Dermato-Venereologica, Vol 100, Iss 17, p adv00302 (2020) |
| ISSN: | 1651-2057 |
| DOI: | 10.2340/00015555-3658 |
| Popis: | Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patients with atopic dermatitis. C-nociceptor-specific electrical stimulation was applied to areas of eczema-affected and non-affected skin in 26 patients with atopic dermatitis. Single half-sine wave pulses (500 ms, 0.2–1 mA) induced itch in 9 patients in eczema-affected areas of the skin (numerical rating scale 5 ± 1), but pain in control skin (numerical rating scale 6 ± 1).Sinusoidal stimuli (4 Hz, 10 pulses, 0.025–0.4 mA) evoked itch in only 3 patients in eczema-affected areas of the skin but on delivering pulses for one minute (0.05–0.2 mA) 48% of the patients (n= 12) reported itch with numerical rating scale 4 ± 1 in areas of eczema-affected skin. The number of patients reporting itch in eczema-affected areas of the skin increased with longer stimulation (p |
| Databáze: | OpenAIRE |
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