Role of amygdaloid nuclei in the anxiolytic-like effect of nociceptin/orphanin FQ in rats
| Autor: | Akihisa Toda, Shigenori Watanabe, Reiko Eyanagi, Hidemori Uchiyama, Takato Hiranita |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Elevated plus maze medicine.medical_specialty Microinjections medicine.drug_class Vasodilator Agents NOP Anxiety Anxiolytic Amygdala Rats Sprague-Dawley Piperidines Internal medicine medicine Animals Maze Learning Opioid peptide Chemistry General Neuroscience Antagonist Anxiety Disorders Rats Nociceptin receptor Endocrinology medicine.anatomical_structure Anti-Anxiety Agents Opioid Peptides Benzimidazoles Basolateral amygdala |
| Zdroj: | Neuroscience Letters. 431:66-70 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.11.023 |
| Popis: | We investigated the mechanism underlying the anxiolytic actions of the neuropeptide nociceptin/orphanin FQ (N/OFQ) using the elevated plus-maze test and T-maze test. Microinfusions of N/OFQ (10 or 32pmol) into the central amygdala (ACE) increased the time spent in the open arms of the elevated plus-maze (anxiolytic-like effects), whereas microinfusions of N/OFQ (10, 32 or 100 pmol) into the basolateral amygdala (ABL) did not affect the time spent in the open arms. Moreover, microinfusions of N/OFQ (32 pmol) into the ACE impaired escape performance from the open arms of the elevated T-maze (anxiolytic-like effects), but did not change inhibitory avoidance of the open arms. A non-peptidyl N/OFQ receptor (NOP) antagonist, J-113397(1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one) (10 mg/kg, s.c.), blocked the anxiolytic-like effects induced by N/OFQ. These results indicate that the anxiolytic-like effects of N/OFQ might be due to impaired escape performance from the open arms and it implicates the N/OFQ system within the ACE in the mediation of panic action. |
| Databáze: | OpenAIRE |
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