Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer
| Autor: | Lijie Xia, Meizhu He, Jinyao Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Telomerase
Angiogenesis plant-derived natural products cervical cancer Phytochemicals molecular mechanisms Uterine Cervical Neoplasms Antineoplastic Agents Apoptosis Review Drug resistance Biochemistry Microbiology Metastasis Humans Medicine Adverse effect Molecular Biology Cell Proliferation Cervical cancer Biological Products Neovascularization Pathologic treatment business.industry Therapeutic effect medicine.disease QR1-502 Multiple drug resistance Cancer research Female business |
| Zdroj: | Biomolecules, Vol 11, Iss 1539, p 1539 (2021) Biomolecules |
| Popis: | Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects. |
| Databáze: | OpenAIRE |
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