A case-control study on fat-to-muscle ratio and risk of breast cancer

Autor:	Alvaro L. Ronco, Matthias B. Schulze, Tobias Pischon, Heiner Boeing, Eduardo De Stefani, Mandy Schulz
Rok vydání:	2009
Předmět:	Adult Cancer Research medicine.medical_specialty Medicine (miscellaneous) Physiology Breast Neoplasms Overweight Motor Activity Body Mass Index Young Adult Breast cancer Internal medicine Surveys and Questionnaires medicine Confidence Intervals Odds Ratio Humans Risk factor Aged Nutrition and Dietetics Anthropometry business.industry Muscles Odds ratio Middle Aged medicine.disease Endocrinology Logistic Models Oncology Adipose Tissue Risk factors for breast cancer Relative risk Case-Control Studies Multivariate Analysis Body Composition Uruguay Female Breast disease medicine.symptom business Body mass index
Zdroj:	Nutrition and cancer. 61(4)
ISSN:	1532-7914
Popis:	Our objective was to analyze detailed anthropometric characterization for risk of breast cancer in Uruguayan women. The design was a case-control study. The setting was Pereira Rossell Women's Hospital, Montevideo, Uruguay. Subjects were 343 incident breast cancer cases and 1,042 frequency-matched healthy controls who were interviewed on menstrual and reproductive story; and a series of skin folds, circumferences, and diameters were measured to calculate fat and muscle fractions and the derived fat-to-muscle ratio (FMR). Odds ratio (ORs) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Muscle fraction was negatively associated with risk [OR for highest quartile = 0.23, 95% confidence interval (CI) = 0.15-0.34], fat fraction was positively associated (OR = 3.90, 95% CI = 2.62-5.80), and FMR was positively associated (OR = 4.45, 95% CI = 2.99-6.62). Stratified analyses by body mass index levels also showed risk increases for the highest tertiles of FMR, always displaying significant linear trends. Since increases of risk were found in overweight and in normal weight women, results suggest that fractions and amount of muscle and fat components might be risk factors for breast cancer on the basis of currently existing metabolic and immune interrelationships between adipose and muscular tissue given by glutamine, exercise-derived myokines, and other cytokines produced by these tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccabc13a0e59878f27adac2d83f148a4 https://pubmed.ncbi.nlm.nih.gov/19838918 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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