Assessing Impact of Real-World Dosing Irregularities With Lamotrigine Extended-Release and Immediate-Release Formulations by Pharmacokinetic Simulation
| Autor: | John A. Messenheimer, Chao Chen, James Wright, Barry E. Gidal |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Drug Substitution Triazines business.industry Chemistry Pharmaceutical Missed Dose Lamotrigine Pharmacokinetics Computer Systems Delayed-Action Preparations medicine Humans Anticonvulsants Pharmacology (medical) Trough Concentration Dosing Immediate release Extended release Lead (electronics) business medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring. 35:188-193 |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/ftd.0b013e318281891c |
| Popis: | PURPOSE To assess the effect of common dosing irregularities on serum concentrations of antiepileptic drug (AED) lamotrigine for the extended-release (XR) formulation, which is recommended for once-daily dosing (QD), and the immediate-release (IR) formulation, which is typically dosed twice daily (BID). METHODS A pharmacokinetic model was constructed for lamotrigine XR and IR formulations in the presence and absence of comedications. The model was then used to simulate concentration time profiles in scenarios of full compliance and various forms of nonadherence such as a delayed dose, a missed dose, and a doubled dose. RESULTS Lamotrigine steady-state serum concentrations stayed in a narrower range for XR-QD than for IR-BID, despite the more frequent dosing of the latter. At the same daily dose, concentrations with IR-BID were outside the range seen with XR-QD for the majority of the day. For XR-QD, concentration decrease due to dosing delay was small ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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