Effect of Suppression and Stimulation of Erythropoiesis on CFU-E in Mouse Spleen
| Autor: | Dubravka Kapa, Pavle Milenković, Vera Pavlović-Kentera, Lidija Biljanović-Paunović |
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| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Ratón Bone Marrow Cells Stimulation Spleen Biology Colony-Forming Units Assay Mice Internal medicine medicine Animals Blood Transfusion Erythropoiesis Hypoxia Cyclophosphamide Erythropoietin CFU-E Mouse Spleen Hematology General Medicine Hypoxia (medical) medicine.anatomical_structure Endocrinology Depression Chemical Mice Inbred CBA Female Bone marrow medicine.symptom Erythrocyte Transfusion |
| Zdroj: | Acta Haematologica. 72:295-302 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000206405 |
| Popis: | Splenic CFU-E in mice were determined during stimulation and suppression of erythropoiesis by means of the methylcellulose culture system originally used for bone marrow CFU-E. It was found that under steady-state conditions the number of CFU-E in the spleen comprises less than 20% of the CFU-E in the total bone marrow mass. The number of CFU-E decreased with suppression and increased after stimulation of erythropoiesis. The response to exogenous Ep stimulation on day 10 posthypoxia was more pronounced in the spleen than in the bone marrow (the number of CFU-E was 1.6 times greater in the spleen than in the total bone marrow mass) indicating the importance of the spleen in stimulated erythropoiesis in mice. |
| Databáze: | OpenAIRE |
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