Depletion of dietary n-3 fatty acid affects the level of cyclic AMP in rat hippocampus
| Autor: | Atsuko Nanjo, Kiyohito Sato, Kenshiro Fujimoto, Ayako Kanazawa, Fumiaki Banno |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Inositol Phosphates Medicine (miscellaneous) Muscarinic Antagonists Biology Tritium Hippocampus Rats Sprague-Dawley Dietary Fats Unsaturated Internal medicine Muscarinic acetylcholine receptor Fatty Acids Omega-3 medicine Cyclic AMP Hippocampus (mythology) Animals Receptor Unsaturated fatty acid Protein Kinase C chemistry.chemical_classification Nutrition and Dietetics Kinase Antagonist Fatty acid Cyclic AMP-Dependent Protein Kinases Receptors Muscarinic Quinuclidinyl Benzilate Rats Endocrinology chemistry Fatty Acids Unsaturated Female |
| Zdroj: | Journal of nutritional science and vitaminology. 45(5) |
| ISSN: | 0301-4800 |
| Popis: | Prolonged depletion of dietary n-3 fatty acid induces a neurological disturbance. To ascertain the deficit of neurotransmission at the time of n-3 deficiency, the concentrations of cAMP and inositol triphosphate, and the activities of protein kinases A and C were examined in vitro in rat hippocampus. Furthermore, the saturation binding study of [3H]quinuclidinyl benzilate, a specific antagonist to muscarinic cholinergic receptor, was performed. Rats were fed a safflower oil diet as the deficient group and a soybean oil diet as the control group. Hippocampi were obtained from rats in the 3rd generation in the deficient group and in the 2nd generation in the control group. Dietary effect was not observed in the parameters except for the concentration of cAMP, which was significantly higher in the deficient group than in the control group. |
| Databáze: | OpenAIRE |
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