The c- reactive protein to troponin ratio enhances the differentiation of perimyocarditis from acute myocardial infarction
| Autor: | Aharon Frimerman, Avraham Shotan, Ofer Kobo, Simcha R. Meisel, Ariel Roguin, R Natour, N Hamuda, R Abu Fanne, Naama Amsalem, Majdi Saada, M Kleiner Shochat, Carmel Levin, Yaniv Levi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
biology business.industry C-reactive protein General Medicine Critical Care and Intensive Care Medicine medicine.disease Troponin Internal medicine biology.protein Cardiology Medicine Myocardial infarction cardiovascular diseases 18.3.1 - Biomarkers Cardiology and Cardiovascular Medicine business |
| Zdroj: | Eur Heart J Acute Cardiovasc Care |
| Popis: | Funding Acknowledgements Type of funding sources: None. Differentiating perimyocarditis from acute myocardial infarction (AMI) is frequently difficult . Perimyocarditis is primarily an inflammatory disease associated with high C-reactive protein (CRP) and relatively low elevated troponin concentrations, while AMI is characterized by the opposite. We surmised that the CRP/troponin ratio on presentation could improve the differentiation between these two clinical entities. We evaluated the CRP/troponin ratio on presentation among patients consecutively included in a large hospital registry that included 1898 consecutive patients comprising 1025 ST-elevation myocardial infarction (STEMI) patients, 518 Non-STEMI (NSTEMI) patients, and 355 patients diagnosed as perimyocarditis. CRP and troponin were sampled on admission and their ratio was assessed against discharge diagnosis. ROC analysis of the CRP/troponin ratios evaluated the diagnostic accuracy of perimyocarditis against STEMI with or without NSTEMI. Median admission CRP/troponin ratios were 84, 65, and 436 mg × ml/liter × ng in STEMI, NSTEMI and perimyocarditis groups, respectively (p 500 resulted in specificity exceeding 85%. The CRP/troponin ratio is an effective tool that enhances the differentiation between perimyocarditis and AMI. |
| Databáze: | OpenAIRE |
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